TargetMol

SB-267268

Product Code:
 
TAR-T16851
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16851-5mg5mg£1,091.00
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TAR-T16851-50mg50mg£2,143.00
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Quantity:
TAR-T16851-100mg100mg£2,801.00
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This product comes from: United States.
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Further Information

Bioactivity:
SB-267268 inhibits human and mouse αvβ3 (IC50s: 0.68 and 0.29 nM, respectively). SB-267268 is a selective and nonpeptidic alpha(v)beta3 and alpha(v)beta5 integrins antagonist (Kis: 0.9, 0.5 and 0.7 nM for human αvβ3, monkey αvβ3 and human αvβ5, respectively).
CAS:
205678-26-8
Formula:
C22H24F3N3O4
Molecular Weight:
451.446
Purity:
0.98
SMILES:
OC(=O)C[C@@H]1Cc2ccc(OCCCNc3ccccn3)cc2CN(CC(F)(F)F)C1=O

References

1. Wilkinson-Berka JL, et al. SB-267268, a nonpeptidic antagonist of alpha(v)beta3 and alpha(v)beta5 integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1600-5.