TargetMol

TAS05567

Product Code:
 
TAR-T16995
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16995-5mg5mg£1,251.00
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TAR-T16995-50mg50mg£2,464.00
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TAR-T16995-100mg100mg£3,283.00
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Further Information

Bioactivity:
TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, JAK2, KDR, and RET with IC50s of 10 nM, 4.8 nM, 600 nM, and 29 nM, respectively) in a panel of 192 kinases.
CAS:
1429038-15-2
Formula:
C21H29N9O2
Molecular Weight:
439.524
Pathway:
Stem Cells; Angiogenesis; JAK/STAT signaling; Chromatin/Epigenetic; Apoptosis; Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
Cc1cc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)nnc2C(N)=O)cc2cn(nc12)C(C)(C)C
Target:
FLT; c-RET; JAK; Syk

References

1. Hayashi H, et al. TAS05567, a Novel Potent and Selective Spleen Tyrosine Kinase Inhibitor, Abrogates Immunoglobulin-Mediated Autoimmune and Allergic Reactions in Rodent Models. J Pharmacol Exp Ther. 2018 Jul;366(1):84-95.