TargetMol

Y-27632 dihydrochloride

Product Code:
 
TAR-T1725
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T1725-5mg5mg£105.45£111.00
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TAR-T1725-10mg10mg£111.15£117.00
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TAR-T1725-25mg25mg£152.00£160.00
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TAR-T1725-50mg50mg£199.50£210.00
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TAR-T1725-100mg100mg£285.95£301.00
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TAR-T1725-200mg200mg£416.10£438.00
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Further Information

Bioactivity:
Y-27632 is a selective inhibitor of ROCKs including p160ROCK (Ki: 140 nM) and ROCK2 (IC50: 800 nM).
Biological Applications:
Y-27632/Y-27632 2HCl, as a ROCK inhibitor, has significant applications not only in diseases like cancer but also in organoid culture and stem cell research, contributing to the maintenance of cell survival and functionality, thus holding crucial value in various fields. Common applications: 1) Cryopreservation of stem cells: Y-27632 helps prevent dissociation-related cell apoptosis during the low-temperature preservation of stem cells and enhances cell viability post-thaw. 2) Pancreatic ductal adenocarcinoma organoid culture: Y-27632 serves as a supplement to the culture medium. 3) Mouse embryonic stem cells: Y-27632 inhibits the Rho kinase (Rho) in these cells. 4) Human embryonic stem cells and induced pluripotent stem cells (iPSCs): Y-27632 inhibits Rho-associated protein kinase (ROCK). These diverse applications highlight the versatility and importance of Y-27632/Y-27632 2HCl in various research settings, promising advancements in cell biology and regenerative medicine.
CAS:
129830-38-2
Formula:
C14H23Cl2N3O
Long Description:
Y-27632 2HCl, also known as Y-27632 dihydrochloride or trans-4-[(R)-1-aminoethyl]-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride, is the dihydrochloride salt form of Y-27632, exerting the same inhibitory effects as Y-27632.
Molecular Weight:
320.26
Pathway:
Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
Purity:
0.9997
Research Area:
cancer, glaucoma, asthma, erectile dysfunction, insulin resistance, neurodegeneration, osteoporosis, renal failure, fibrosis, and graft-versus-host disease.
SMILES:
Cl.Cl.C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
Target:
ROCK; Apoptosis

References

1. Ishizaki T, et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol. 2000 May;57(5):976-83. 10. Gong-Bo Fu, Wei-Jian Huang, Min Zeng, Xu Zhou, Hong-Ping Wu, Chang-Cheng Liu, Han Wu, Jun Weng, Hong-Dan Zhang, Yong-Chao Cai, Charles Ashton, Min Ding, Dan Tang, Bao-Hua Zhang, Yi Gao, Wei-Feng Yu, Bo Zhai, Zhi-Ying He, Hong-Yang Wang, and He-Xin Yan . Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens [J]. Cell Research. 2019 Jan;29(1):8-22. 2. Watanabe K, et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol. 2007 Jun;25(6):681-6. 3. Xue ZW, et al. Rho-associated coiled kinase inhibitor Y-27632 promotes neuronal-like differentiation of adult human adipose tissue-derived stem cells.Chin Med J (Engl). 2012 Sep;125(18):3332-5. 4. Uehata M, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997 Oct 30;389(6654):990-4. 5. Inan S, et al. Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice. Br J Pharmacol. 2008 Sep;155(1):44-51. 6. Schenke M, Schjeide B M, P?schel G P, et al. Analysis of Motor Neurons Differentiated from Human Induced Pluripotent Stem Cells for the Use in Cell-Based Botulinum Neurotoxin Activity Assays[J]. Toxins. 2020, 12(5): 276. 7. Chen X, Lin J, Hu T, et al. Galectin?3 exacerbates ox?LDL?mediated endothelial injury by inducing inflammation via integrin ?1?RhoA?JNK signaling activation[J]. Journal of cellular physiology. 2019 Jul;234(7):10990-11000. 8. Li Z, Luo W, Fang S, et al. Prostacyclin facilitates vascular smooth muscle cell phenotypic transformation via activating TP receptors when IP receptors are deficient[J]. Acta Physiologica. 2020: e13555. 9. Zhu Y, Wang L, Yu H, et al. In situ generation of human brain organoids on a micropillar array[J]. Lab on a Chip. 2017 Aug 22;17(17):2941-2950.