TargetMol

SB-431542

Product Code:
 
TAR-T1726
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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TAR-T1726-5mg5mg£105.45£111.00
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TAR-T1726-10mg10mg£129.20£136.00
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TAR-T1726-1mL1 mL * 10 mM (in DMSO)£135.85£143.00
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TAR-T1726-25mg25mg£190.95£201.00
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TAR-T1726-50mg50mg£292.60£308.00
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TAR-T1726-100mg100mg£485.45£511.00
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TAR-T1726-200mg200mg£490.20£516.00
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Further Information

Bioactivity:
SB-431542 is a potent and selective inhibitor of ALK5 (IC50: 94 nM) and is also an inhibitor of ALK4 (IC50: 140 nM) and ALK7.
Biological Applications:
There are many small molecules used in reprogramming, which can be categorized into four types: metabolic regulators, epigenetic modifiers, signaling modulators, and aging inhibitors. In this issue, we introduce three commonly used small molecule signaling modulators in reprogramming: 1) A 83-01 and SB-431542 inhibit the activity of TGF-β type I receptors ALK5/4/7 kinases. TGF-β plays a crucial role in stem cell culture. Stem cells possess active paracrine functions and can secrete a large amount of transforming growth factors through exosomes. TGF-β promotes stem cell proliferation, aiding in the maintenance of their numbers. A 83-01 and SB-431542, as TGF-β inhibitors, are commonly used to inhibit the differentiation of iPSCs and maintain the self-renewal of cells in vitro. A 83-01 is generally used for the culture of gastrointestinal, hepatic, prostatic, and mammary organoids, while SB-431542 is typically used for the culture of lung and inner ear organoids. 2) SB 202190 is a potent p38 MAPK kinase inhibitor that can induce human embryonic stem cells to differentiate into cardiac muscle cells and promote the self-renewal of neural stem cells. It can be used for the culture of gastrointestinal, mammary, and prostatic organoids.
CAS:
301836-41-9
Formula:
C22H16N4O3
Long Description:
SB-431542, also known as SB 431542 or 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide hydrate, is a selective inhibitor of transforming growth factor-beta (TGF-β) type I receptor ALK5, with an IC50 of 94 nM. It also exhibits inhibitory activity against ALK4 and ALK7 to some extent, with no inhibitory effect on other proteins. SB-431542 is commonly used for inducing differentiation in stem cells.
Molecular Weight:
384.395
Pathway:
Stem Cells; Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.9987
Research Area:
Organoid
SMILES:
NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccccn1)-c1ccc2OCOc2c1
Target:
ALK; TGF-beta/Smad

References

1. Callahan JF, et al. Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5). J Med Chem. 2002 Feb 28;45(5):999-1001. 2. Laping NJ, et al. Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol Pharmacol. 2002 Jul;62(1):58-64. 3. Chambers SM, et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol. 2009 Mar;27(3):275-80. 4. Tanaka H, et al. Transforming growth factor ? signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity. Oncol Rep. 2010 Dec;24(6):1637-43. 5. Sato M, et al. Differential Proteome Analysis Identifies TGF-?-Related Pro-Metastatic Proteins in a 4T1 Murine Breast Cancer Model. PLoS One. 2015 May 18;10(5):e0126483. 6. Ma J, et al. Growth differentiation factor 11 improves neurobehavioral recovery and stimulates angiogenesis in rats subjected to cerebral ischemia/reperfusion. Brain Res Bull. 2018 Feb 9;139:38-47. 7. Duan F, Huang R, Zhang F, et al. Biphasic modulation of insulin signaling enables highly efficient hematopoietic differentiation from human pluripotent stem cells[J]. Stem cell research & therapy. 2018 Jul 27;9(1):205. 8. Xiong, Yanlu, et al. TFAP2A potentiates lung adenocarcinoma metastasis by a novel miR-16 family/TFAP2A/PSG9/TGF-? signaling pathway.?. Cell Death & Disease?. 12.4 (2021): 1-13. 9. Chen F, Gao Q, Wei A, et al. Histone deacetylase 3 aberration inhibits Klotho transcription and promotes renal fibrosis[J]. Cell Death & Differentiation. 2020: 1-12.