TargetMol

Aprepitant

Product Code:
 
TAR-T1743
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1743-5mg5mg£109.00
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TAR-T1743-1mL1 mL * 10 mM (in DMSO)£117.00
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TAR-T1743-10mg10mg£117.00
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TAR-T1743-50mg50mg£136.00
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TAR-T1743-100mg100mg£149.00
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TAR-T1743-200mg200mg£164.00
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Quantity:
TAR-T1743-500mg500mg£189.00
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This product comes from: United States.
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Further Information

Bioactivity:
Aprepitant is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inducer, and Cytochrome P450 3A4 Inducer.
CAS:
170729-80-3
Formula:
C23H21F7N4O3
Molecular Weight:
534.435
Pathway:
GPCR/G Protein; Microbiology/Virology; Proteases/Proteasome; Neuroscience
Purity:
0.999
SMILES:
C[C@@H](O[C@H]1OCCN(Cc2nc(=O)[nH][nH]2)[C@H]1c1ccc(F)cc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Target:
HIV Protease; Antibacterial; Antibiotic; Neurokinin receptor

References

1. Tattersall FD, et al. Neuropharmacology, 2000, 39(4), 652-663. 2. Navari RM. Expert Rev Anticancer Ther, 2004, 4(5), 715-724. 6. Mannangatti P, et al. Differential effects of aprepitant, a clinically used neurokinin-1 receptor antagonist on the expression of conditioned psychostimulant versus opioid reward. Psychopharmacology (Berl). 2017 Feb;234(4):695-705.