TargetMol

Clemizole hydrochloride

Product Code:
 
TAR-T1822L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1822L-5mg5mg£102.00
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Quantity:
TAR-T1822L-1mL1 mL * 10 mM (in DMSO)£105.00
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TAR-T1822L-10mg10mg£122.00
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TAR-T1822L-25mg25mg£173.00
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TAR-T1822L-50mg50mg£269.00
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TAR-T1822L-100mg100mg£386.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Clemizole hydrochloride is an antagonist for H1 histamine receptor. According to the research, Clemizole hydrochloride can inhibit hepatitis C virus (HCV) replication and NS4B's RNA binding.
CAS:
1163-36-6
Formula:
C19H21Cl2N3
Molecular Weight:
362.3
Pathway:
Microbiology/Virology; Neuroscience; Proteases/Proteasome; GPCR/G Protein; Immunology/Inflammation
Purity:
0.9991
SMILES:
Cl.Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc23)cc1
Target:
HCV Protease; Histamine Receptor

References

1. Einav S, et al. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol. 2008 Sep;26(9):1019-27. 2. Richter JM, et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. 3. Nishimura T, et al. Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J Pharmacol Exp Ther. 2013 Feb;344(2):388-96.