TargetMol

PR-619

Product Code:
 
TAR-T1862
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1862-5mg5mg£107.00
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Quantity:
TAR-T1862-10mg10mg£128.00
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Quantity:
TAR-T1862-1mL1 mL * 10 mM (in DMSO)£134.00
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Quantity:
TAR-T1862-25mg25mg£171.00
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Quantity:
TAR-T1862-50mg50mg£228.00
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Quantity:
TAR-T1862-100mg100mg£309.00
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Quantity:
TAR-T1862-200mg200mg£429.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs).
CAS:
2645-32-1
Formula:
C7H5N5S2
Molecular Weight:
223.27
Pathway:
Ubiquitination; Cell Cycle/Checkpoint; Apoptosis; DNA Damage/DNA Repair; Autophagy
Purity:
0.9983
SMILES:
Nc1nc(N)c(SC#N)cc1SC#N
Target:
Apoptosis; DUB; Autophagy

References

1. Altun M, et al. Chem Biol, 2011, 18(11), 1401-1412. 2. Song P, Yang S, Hua H, et al. The regulatory protein GADD34 inhibits TRAIL-induced apoptosis via TRAF6/ERK-dependent stabilization of myeloid cell leukemia 1 in liver cancer cells[J]. Journal of Biological Chemistry, 2019: jbc. RA118. 006029.