TargetMol

Fenretinide

Product Code:
 
TAR-T1872
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1872-5mg5mg£98.00
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TAR-T1872-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T1872-10mg10mg£114.00
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TAR-T1872-25mg25mg£134.00
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TAR-T1872-50mg50mg£149.00
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TAR-T1872-100mg100mg£173.00
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Quantity:
TAR-T1872-200mg200mg£226.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Fenretinide is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.
CAS:
65646-68-6
Formula:
C26H33NO2
Molecular Weight:
391.555
Pathway:
Autophagy; Metabolism
Purity:
0.9972
SMILES:
CC(C=CC1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(=O)Nc1ccc(O)cc1
Target:
Retinoid Receptor; Autophagy

References

1. Apraiz, Aintzane., et al. Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death. Biochemistry and Cell Biology (2012), 90(2), 209-223. 2. Bikman, Benjamin T., et al. Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis. Journal of Biological Chemistry (2012), 287(21), 17426-17437. 3. Cooper JP, et al. Fenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure. Br J Pharmacol. 2011 Jul;163(6):1263-75. 4. Golubkov V, et al. Action of fenretinide (4-HPR) on ovarian cancer and endothelial cells. Anticancer Res. 2005 Jan-Feb;25(1A):249-53.