TargetMol

Kobe0065

Product Code:
 
TAR-T1876
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1876-5mg5mg£102.00
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TAR-T1876-10mg10mg£116.00
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TAR-T1876-25mg25mg£149.00
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TAR-T1876-50mg50mg£185.00
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TAR-T1876-100mg100mg£258.00
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TAR-T1876-200mg200mg£381.00
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TAR-T1876-500mg500mg£589.00
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Further Information

Bioactivity:
Kobe0065 is a novel and effective small-molecule compound inhibiting Ras?Raf interaction by SBDD; shows potent activity to competitively inhibit the binding of H-Ras?GTP to c-Raf-1 RBD with a Ki value of 46 ? 13 μM.
CAS:
436133-68-5
Formula:
C15H11ClF3N5O4S
Molecular Weight:
449.79
Pathway:
GPCR/G Protein; MAPK; Apoptosis
Purity:
0.9976
SMILES:
Cc1ccc(NC(=S)NNc2c(cc(cc2[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O)cc1Cl
Target:
Apoptosis; Raf; Ras

References

1. Shima F, et al. Proc Natl Acad Sci U S A. 2013, 110(20):8182-7.