TargetMol

AM251

Product Code:
 
TAR-T1915
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1915-5mg5mg£105.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T1915-1mL1 mL * 10 mM (in DMSO)£122.00
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Quantity:
TAR-T1915-10mg10mg£128.00
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Quantity:
TAR-T1915-25mg25mg£177.00
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Quantity:
TAR-T1915-50mg50mg£259.00
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Quantity:
TAR-T1915-100mg100mg£350.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49 nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39 nM).
CAS:
183232-66-8
Formula:
C22H21Cl2IN4O
Molecular Weight:
555.24
Pathway:
GPCR/G Protein; Endocrinology/Hormones
Purity:
0.9788
SMILES:
Cc1c(nn(c1-c1ccc(I)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1
Target:
Cannabinoid Receptor; GPR

References

1. Liao C, et al. Basic Clin Pharmacol Toxicol, 2004, 94(2), 73-78. 10. Bowden G D, Land K M, O'Connor R M, et al. High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth[J]. International Journal for Parasitology: Drugs and Drug Resistance. 2018 Apr?8(1): 137-144. 2. Thewke D, et al. Biochem Biophys Res Commun, 2009, 381(2), 181-186. 3. Chambers AP, et al. Physiol Behav, 2004, 82(5), 863-869. 4. McLaughlin PJ, et al. Psychopharmacology (Berl), 2005, 180(2), 286-293. 5. de Oliveira Alvares L, et al. Neurobiol Learn Mem, 2005, 83(2), 119-124. 6. Komaki A, et al. Study the Effect of Endocannabinoid System on Rat Behavior in Elevated Plus-Maze. Basic Clin Neurosci. 2015 Jul;6(3):147-53. 7. Carey LM, et al. A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase. Mol Pain. 2016 May 13;12. pii: 1744806916649192. 8. Jiang X, et al. Role of cannabinoid receptor type 1 in tibial and pudendal neuromodulation of bladder overactivity in cats. Am J Physiol Renal Physiol. 2017 Mar 1;312(3):F482-F488. 9. Sun L, et al. Endocannabinoid activation of CB1 receptors contributes to long-lasting reversal of neuropathic pain by repetitive spinal cord stimulation. Eur J Pain. 2017 May;21(5):804-814.