TargetMol

Ro 20-1724

Product Code:
 
TAR-T19706
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T19706-100mg100mgEnquire
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TAR-T19706-50mg50mgEnquire
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Further Information

Bioactivity:
Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1 μM.
CAS:
29925-17-5
Formula:
C15H22N2O3
Molecular Weight:
278.352
Pathway:
Metabolism
Purity:
0.9914
SMILES:
CCCCOc1cc(CC2CNC(=O)N2)ccc1OC
Target:
PDE

References

1. Reeves ML, Leigh BK, England PJ. The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors. Biochem J. 1987 Jan 15;241(2):535-41. 2. Sharma V, et al. Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats. Pharmacol Biochem Behav. 2012;101(2):239-245. 3. Morrison MR, Hall CL, Pardue S, Brodeur R, Baskin F, Rosenberg RN. The synthesis and degradation of poly(a)-containing mRNAs in mouse neuroblastoma cells treated with dibutyryl cAMP or with Ro20-1724. J Neurochem. 1980 Jan;34(1):50-8.