TargetMol

Evoxine

Product Code:
 
TAR-T19854
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T19854-5mg5mg£1,235.00
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Further Information

Bioactivity:
Evoxine is a selective inhibitor of CO2-induced immune suppression. It inhibits hypercapnic suppression of interleukin-6 and the chemokine CCL2 expression in human THP-1 macrophages.
CAS:
522-11-2
Formula:
C18H21NO6
Molecular Weight:
347.37
Purity:
0.98
SMILES:
CC(O)(C)C(O)COC1=CC=C2C(OC)=C3C(OC=C3)=NC2=C1OC

References

1. Kouam ADK, Bissoue AN, Tcho AT, Happi EN, Waffo AFK, Sewald N, Wansi JD. Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). Molecules. 2017 Dec 21;23(1). pii: E13. doi: 10.3390/molecules23010013. PubMed PMID: 29267257. 2. Helenius IT, Nair A, Bittar HE, Sznajder JI, Sporn PH, Beitel GJ. Focused Screening Identifies Evoxine as a Small Molecule That Counteracts CO2-Induced Immune Suppression. J Biomol Screen. 2016 Apr;21(4):363-71. doi: 10.1177/1087057115624091. Epub 2015 Dec 23. PubMed PMID: 26701099; PubMed Central PMCID: PMC5096368. 3. Kiplimo JJ, Islam MS, Koorbanally NA. A novel flavonoid and furoquinoline alkaloids from Vepris glomerata and their antioxidant activity. Nat Prod Commun. 2011 Dec;6(12):1847-50. PubMed PMID: 22312722. 4. Chu CC, Pan KL, Yao HT, Hsu JT. Development of a whole-cell screening system for evaluation of the human CYP1A2-mediated metabolism. Biotechnol Bioeng. 2011 Dec;108(12):2932-40. doi: 10.1002/bit.23256. Epub 2011 Aug 1. PubMed PMID: 21755496.