TargetMol

GEBR-7b

Product Code:
 
TAR-T19865
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T19865-5mg5mg£111.00
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Quantity:
TAR-T19865-1mL1 mL * 10 mM (in DMSO)£118.00
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TAR-T19865-10mg10mg£131.00
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TAR-T19865-25mg25mg£173.00
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TAR-T19865-50mg50mg£225.00
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Quantity:
TAR-T19865-100mg100mg£301.00
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Quantity:
TAR-T19865-200mg200mg£417.00
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Quantity:
TAR-T19865-500mg500mg£643.00
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Further Information

Bioactivity:
GEBR-7b is a phosphodiesterase-4 (PDE4) inhibitor.
CAS:
67387-76-2
Formula:
C13H16O3
Molecular Weight:
220.268
Pathway:
Metabolism
Purity:
0.9954
SMILES:
COc1ccc(C=O)cc1OC1CCCC1
Target:
PDE

References

1. Bruno O, Brullo C, Arduino N, Schenone S, Ranise A, Bondavalli F, Ottonello L, Dapino P, Dallegri F. Synthesis and biological evaluation of neutrophilic inflammation inhibitors. Farmaco. 2004 Mar;59(3):223-35. 2. Sierksma AS, van den Hove DL, Pfau F, Philippens M, Bruno O, Fedele E, Ricciarelli R, Steinbusch HW, Vanmierlo T, Prickaerts J. Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D. Neuropharmacology. 2014 Feb;77:120-30. doi: 10.1016/j.neuropharm.2013.09.015. Epub 2013 Sep 22. PubMed PMID: 24067928. 3. Liu X, Guo H, Sayed MD, Lu Y, Yang T, Zhou D, Chen Z, Wang H, Wang C, Xu J. cAMP/PKA/CREB/GLT1 signaling involved in the antidepressant-like effects of phosphodiesterase 4D inhibitor (GEBR-7b) in rats. Neuropsychiatr Dis Treat. 2016 Jan 21;12:219-27. doi: 10.2147/NDT.S90960. eCollection 2016. PubMed PMID: 26855578; PubMed Central PMCID: PMC4725689. 4. Bruno O, Fedele E, Prickaerts J, Parker LA, Canepa E, Brullo C, Cavallero A, Gardella E, Balbi A, Domenicotti C, Bollen E, Gijselaers HJ, Vanmierlo T, Erb K, Limebeer CL, Argellati F, Marinari UM, Pronzato MA, Ricciarelli R. GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. Br J Pharmacol. 2011 Dec;164(8):2054-63. doi: 10.1111/j.1476-5381.2011.01524.x. PubMed PMID: 21649644; PubMed Central PMCID: PMC3246667.