TargetMol

Lipstatin

Product Code:
 
TAR-T20441
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T20441-5mg5mg£850.00
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Further Information

Bioactivity:
Lipstatin is a potent inhibitor of the pancreas lipase. It is reported to be useful in the treatment and/or prevention of obesity and related diseases.
CAS:
96829-59-3
Formula:
C29H49NO5
Molecular Weight:
491.713
Purity:
0.98
SMILES:
CCCCCC[C@@H]1C(C[C@H](CC=C/CC=C/CCCCC)OC(=O)[C@H](CC(C)C)NC=O)OC1=O

References

1. Zhu T, Wang L, Wang W, Hu Z, Yu M, Wang K, Cui Z. Enhanced production of lipstatin from Streptomyces toxytricini by optimizing fermentation conditions and medium. J Gen Appl Microbiol. 2014;60(3):106-11. PubMed PMID: 25008166. 2. Bai T, Zhang D, Lin S, Long Q, Wang Y, Ou H, Kang Q, Deng Z, Liu W, Tao M. Operon for biosynthesis of lipstatin, the Beta-lactone inhibitor of human pancreatic lipase. Appl Environ Microbiol. 2014 Dec;80(24):7473-83. doi: 10.1128/AEM.01765-14. Epub 2014 Sep 19. PubMed PMID: 25239907; PubMed Central PMCID: PMC4249243. 3. Kumar P, Dubey KK. Modulation of fatty acid metabolism and tricarboxylic acid cycle to enhance the lipstatin production through medium engineering in Streptomyces toxytricini. Bioresour Technol. 2016 Aug;213:64-68. doi: 10.1016/j.biortech.2016.01.133. Epub 2016 Feb 11. PubMed PMID: 26897471. 4. Demirev AV, Khanal A, Sedai BR, Lim SK, Na MK, Nam DH. The role of acyl-coenzyme A carboxylase complex in lipstatin biosynthesis of Streptomyces toxytricini. Appl Microbiol Biotechnol. 2010 Jul;87(3):1129-39. doi: 10.1007/s00253-010-2587-2. Epub 2010 May 2. PubMed PMID: 20437235; PubMed Central PMCID: PMC2886142.