TargetMol

Heliotrine

Product Code:
 
TAR-T20523
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T20523-5mg5mg£850.00
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Further Information

Bioactivity:
Heliotrine leads to apoptosis of the human hepatoma cell line HepaRG.
CAS:
303-33-3
Formula:
C16H27NO5
Molecular Weight:
313.394
Purity:
0.98
SMILES:
CO[C@H](C)[C@@](O)(C(C)C)C(=O)OCC1=CCN2CC[C@H](O)[C@@H]12

References

1. Waizenegger J, Braeuning A, Templin M, Lampen A, Hessel-Pras S. Structure-dependent induction of apoptosis by hepatotoxic pyrrolizidine alkaloids in the human hepatoma cell line HepaRG: Single versus repeated exposure. Food Chem Toxicol. 2018 Apr;114:215-226. doi: 10.1016/j.fct.2018.02.036. Epub 2018 Feb 16. PubMed PMID: 29458164. 2. He X, Xia Q, Woodling K, Lin G, Fu PP. Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides. J Food Drug Anal. 2017 Oct;25(4):984-991. doi: 10.1016/j.jfda.2017.09.001. Epub 2017 Sep 19. PubMed PMID: 28987376. 3. Huybrechts B, Callebaut A. Pyrrolizidine alkaloids in food and feed on the Belgian market. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(11):1939-51. doi: 10.1080/19440049.2015.1086821. Epub 2015 Oct 15. PubMed PMID: 26373269. 4. Luckert C, Hessel S, Lenze D, Lampen A. Disturbance of gene expression in primary human hepatocytes by hepatotoxic pyrrolizidine alkaloids: A whole genome transcriptome analysis. Toxicol In Vitro. 2015 Oct;29(7):1669-82. doi: 10.1016/j.tiv.2015.06.021. Epub 2015 Jun 20. PubMed PMID: 26100227.