TargetMol

Senkirkin

Product Code:
 
TAR-T20635
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T20635-5mg5mg£552.00
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Quantity:
TAR-T20635-10mg10mg£898.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
Senkirkin is a pyrrolizidine alkaloid with hepatotoxicity.
CAS:
2318-18-5
Formula:
C19H28NO6
Molecular Weight:
366.433
Purity:
0.98
SMILES:
[H][C@]12CC[N+]3(C)CC=C(COC(=O)[C@](C)(O)[C@H](C)CC(=CC)C(=O)O1)[C@]23O

References

1. Fashe MM, Juvonen RO, Petsalo A, Veps?l?inen J, Pasanen M, Rahnasto-Rilla M. In silico prediction of the site of oxidation by cytochrome P450 3A4 that leads to the formation of the toxic metabolites of pyrrolizidine alkaloids. Chem Res Toxicol. 2015 Apr 20;28(4):702-10. doi: 10.1021/tx500478q. Epub 2015 Feb 17. PubMed PMID: 25651456. 2. Fashe MM, Juvonen RO, Petsalo A, Rahnasto-Rilla M, Auriola S, Soininen P, Veps?l?inen J, Pasanen M. Identification of a new reactive metabolite of pyrrolizidine alkaloid retrorsine: (3H-pyrrolizin-7-yl)methanol. Chem Res Toxicol. 2014 Nov 17;27(11):1950-7. doi: 10.1021/tx5002964. Epub 2014 Oct 21. PubMed PMID: 25295702. 3. Skaanild MT, Friis C, Brimer L. Interplant alkaloid variation and Senecio vernalis toxicity in cattle. Vet Hum Toxicol. 2001 Jun;43(3):147-51. PubMed PMID: 11383654.