TargetMol

Lobenzarit

Product Code:
 
TAR-T20799
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T20799-5mg5mg£270.00
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TAR-T20799-50mg50mg£1,026.00
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Quantity:
TAR-T20799-100mg100mg£1,564.00
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This product comes from: United States.
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Further Information

Bioactivity:
Lobenzarit, an immunomodulator, is most frequently used to treat arthritis. Its chemical scaffold has been repurposed to tryptophan biosynthesis in Mycobacterium tuberculosis
CAS:
63329-53-3
Formula:
C14H10ClNO4
Molecular Weight:
291.68
Purity:
0.98
SMILES:
O=C(O)C1=CC=C(Cl)C=C1NC2=CC=CC=C2C(O)=O

References

1. Evans GL, Gamage SA, Bulloch EM, Baker EN, Denny WA, Lott JS. Repurposing the chemical scaffold of the anti-arthritic drug Lobenzarit to target tryptophan biosynthesis in Mycobacterium tuberculosis. Chembiochem. 2014 Apr 14;15(6):852-64. doi: 10.1002/cbic.201300628. Epub 2014 Mar 12. Erratum in: Chembiochem. 2015 Mar 23;16(5):706. Chembiochem. 2015 Mar 23;16(5):706. PubMed PMID: 24623674. 2. Evans GL, Gamage SA, Bulloch EM, Baker EN, Denny WA, Lott JS. Corrigendum: Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis. Chembiochem. 2015 Mar 23;16(5):706. doi: 10.1002/cbic.201500098. Epub 2015 Mar 11. PubMed PMID: 26177917. 3. Remirez D, Commandeur JN, Groot E, Vermeulen NP. Mechanism of protection of lobenzarit against paracetamol-induced toxicity in rat hepatocytes. Eur J Pharmacol. 1995 Dec 7;293(4):301-8. PubMed PMID: 8748682. 4. Sakane N, Yoshida T, Umekawa T, Miyazaki R, Kondo M. Nephrogenic diabetes insipidus induced by lobenzarit disodium treatment in patients with rheumatoid arthritis. Intern Med. 1996 Feb;35(2):119-22. Review. PubMed PMID: 8680099.