TargetMol

Citalopram

Product Code:
 
TAR-T20828
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Citalopram, a furancarbonitrile, is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. It is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants. Citalopram is also effective in reducing ethanol uptake in alcoholics.
CAS:
59729-33-8
Formula:
C20H21FN2O
Molecular Weight:
324.399
Purity:
0.98
SMILES:
CN(C)CCCC1(OCc2cc(ccc12)C#N)c1ccc(F)cc1

References

1. Cooke MJ, Waring WS. Citalopram and cardiac toxicity. Eur J Clin Pharmacol. 2013 Apr;69(4):755-60. doi: 10.1007/s00228-012-1408-1. Epub 2012 Sep 21. Review. PubMed PMID: 22996077. 2. Richter T, Alusik S, Paluch Z, Burianova I, Cybulja A, Sadilkova L. Suppressive effect of citalopram on plasma concentrations of thromboxane B2. Scand J Clin Lab Invest. 2015 Nov;75(7):615-20. doi: 10.3109/00365513.2015.1066848. Epub 2015 Jul 28. PubMed PMID: 26205292. 3. Drye LT, Spragg D, Devanand DP, Frangakis C, Marano C, Meinert CL, Mintzer JE, Munro CA, Pelton G, Pollock BG, Porsteinsson AP, Rabins PV, Rosenberg PB, Schneider LS, Shade DM, Weintraub D, Yesavage J, Lyketsos CG; CitAD Research Group. Changes in QTc interval in the citalopram for agitation in Alzheimer's disease (CitAD) randomized trial. PLoS One. 2014 Jun 10;9(6):e98426. doi: 10.1371/journal.pone.0098426. eCollection 2014. PubMed PMID: 24914549; PubMed Central PMCID: PMC4051660. 4. Velez de Mendizabal N, Jackson K, Eastwood B, Swanson S, Bender DM, Lowe S, Bies RR. A population PK model for citalopram and its major metabolite, N-desmethyl citalopram, in rats. J Pharmacokinet Pharmacodyn. 2015 Dec;42(6):721-33. doi: 10.1007/s10928-015-9448-7. Epub 2015 Sep 22. PubMed PMID: 26395999.