TargetMol

Dibemethine

Product Code:
 
TAR-T20910
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T20910-5mg5mg£850.00
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Further Information

Bioactivity:
Dibemethine is active against chloroquinone-resistant Plasmodium falciparum by the inhibition of P. falciparum chloroquine-resistance transporter (PfCRT).
CAS:
102-05-6
Formula:
C15H17N
Molecular Weight:
211.308
Purity:
0.98
SMILES:
CN(Cc1ccccc1)Cc1ccccc1

References

1. Joshi MC, Okombo J, Nsumiwa S, Ndove J, Taylor D, Wiesner L, Hunter R, Chibale K, Egan TJ. 4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice. J Med Chem. 2017 Dec 28;60(24):10245-10256. doi: 10.1021/acs.jmedchem.7b01537. Epub 2017 Dec 7. PubMed PMID: 29185748. 2. Zishiri VK, Joshi MC, Hunter R, Chibale K, Smith PJ, Summers RL, Martin RE, Egan TJ. Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT). J Med Chem. 2011 Oct 13;54(19):6956-68. doi: 10.1021/jm2009698. Epub 2011 Sep 13. PubMed PMID: 21875063. 3. Zishiri VK, Hunter R, Smith PJ, Taylor D, Summers R, Kirk K, Martin RE, Egan TJ. A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT. Eur J Med Chem. 2011 May;46(5):1729-42. doi: 10.1016/j.ejmech.2011.02.026. Epub 2011 Feb 22. PubMed PMID: 21396749.