TargetMol

Adenanthin

Product Code:
 
TAR-T21033
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21033-5mg5mg£634.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T21033-10mg10mg£1,008.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
Adenanthin, a natural inhibitor of thiol-dependent antioxidant enzymes, impairs the effector functions of human natural killer cells.
CAS:
111917-59-0
Formula:
C26H34O9
Molecular Weight:
490.549
Purity:
0.98
SMILES:
[H][C@]12C[C@@]3([C@@H](OC(C)=O)C(=O)[C@]4([H])C(C)(C)[C@@H](O)C[C@H](OC(C)=O)[C@@]4(C)[C@]3([H])[C@H](C1)OC(C)=O)C(=O)C2=C

References

1. Siernicka M, Winiarska M, Bajor M, Firczuk M, Muchowicz A, Bobrowicz M, Fauriat C, Golab J, Olive D, Zagozdzon R. Adenanthin, a new inhibitor of thiol-dependent antioxidant enzymes, impairs the effector functions of human natural killer cells. Immunology. 2015 Sep;146(1):173-83. doi: 10.1111/imm.12494. Epub 2015 Jul 8. PubMed PMID: 26094816; PubMed Central PMCID: PMC4552512. 2. Soethoudt M, Peskin AV, Dickerhof N, Paton LN, Pace PE, Winterbourn CC. Interaction of adenanthin with glutathione and thiol enzymes: selectivity for thioredoxin reductase and inhibition of peroxiredoxin recycling. Free Radic Biol Med. 2014 Dec;77:331-9. doi: 10.1016/j.freeradbiomed.2014.09.025. Epub 2014 Oct 5. PubMed PMID: 25289458. 3. Hou JK, Huang Y, He W, Yan ZW, Fan L, Liu MH, Xiao WL, Sun HD, Chen GQ. Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells. Cell Death Dis. 2014 Sep 4;5:e1400. doi: 10.1038/cddis.2014.345. PubMed PMID: 25188510; PubMed Central PMCID: PMC4540188. 4. Muchowicz A, Firczuk M, Chlebowska J, Nowis D, Stachura J, Barankiewicz J, Trzeciecka A, K?ossowski S, Ostaszewski R, Zago?d?on R, Pu JX, Sun HD, Golab J. Adenanthin targets proteins involved in the regulation of disulphide bonds. Biochem Pharmacol. 2014 May 15;89(2):210-6. doi: 10.1016/j.bcp.2014.02.022. Epub 2014 Mar 11. PubMed PMID: 24630929.