TargetMol

PSI-6206

Product Code:
 
TAR-T2117
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2117-10mg10mg£104.00
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TAR-T2117-1mL1 mL * 10 mM (in DMSO)£107.00
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TAR-T2117-25mg25mg£119.00
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TAR-T2117-50mg50mg£137.00
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Quantity:
TAR-T2117-100mg100mg£163.00
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This product comes from: United States.
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Further Information

Bioactivity:
PSI-6206 (RO2433) is a selective HCV RNA polymerase inhibitor.
CAS:
863329-66-2
Formula:
C10H13FN2O5
Molecular Weight:
260.221
Pathway:
Proteases/Proteasome; Microbiology/Virology
Purity:
0.9933
SMILES:
C[C@@]1(F)[C@H](O)[C@@H](CO)O[C@H]1n1ccc(=O)[nH]c1=O
Target:
HCV Protease

References

1. Clark JL, et al. Design, Synthesis, and Antiviral Activity of 2'-Deoxy-2'-fluoro-2'-C-methyl-cytidine, a Potent Inhibitor of Hepatitis C Virus Replication. J Med Chem. 2005 Aug 25;48(17):5504-8. 2. Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12;282(41):29 3. Wang P, et al. An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J Org Chem. 2009 Sep 4;74(17):6819-24.