TargetMol

Methylguanidine hydrochloride

Product Code:
 
TAR-T21215
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T21215-5mg5mg£850.00
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Further Information

Bioactivity:
Methylguanidine hydrochloride is used in the synthesis of biaryl derivatives which were evaluated as BACE1 inhibitors.
CAS:
22661-87-6
Formula:
C2H8ClN3
Molecular Weight:
109.56
Purity:
0.98
SMILES:
N(C(N)=N)C.Cl

References

1. Bosco AM, Almeida BFM, Pereira PP, Dos Santos DB, Neto ?JS, Ferreira WL, Ciarlini PC. The uremic toxin methylguanidine increases the oxidative metabolism and accelerates the apoptosis of canine neutrophils. Vet Immunol Immunopathol. 2017 Mar;185:14-19. doi: 10.1016/j.vetimm.2017.01.006. Epub 2017 Jan 28. PubMed PMID: 28241998. 2. Noda Y, Masumizu T, Mori A. The Anticonvulsant Zonisamide Inhibits Hydroxyl Radical Generated from Methylguanidine. Acta Med Okayama. 2016 Oct;70(5):371-375. PubMed PMID: 27777429. 3. Oshima N, Onimaru H, Matsubara H, Uchida T, Watanabe A, Takechi H, Nishida Y, Kumagai H. Uric acid, indoxyl sulfate, and methylguanidine activate bulbospinal neurons in the RVLM via their specific transporters and by producing oxidative stress. Neuroscience. 2015 Sep 24;304:133-45. doi: 10.1016/j.neuroscience.2015.07.055. Epub 2015 Jul 28. PubMed PMID: 26208844. 4. Marzocco S, Di Paola R, Serraino I, Sorrentino R, Meli R, Mattaceraso G, Cuzzocrea S, Pinto A, Autore G. Effect of methylguanidine in carrageenan-induced acute inflammation in the rats. Eur J Pharmacol. 2004 Jan 26;484(2-3):341-50. PubMed PMID: 14744621.