TargetMol

SAR-020106

Product Code:
 
TAR-T21331
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21331-1mg1mg£106.00
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TAR-T21331-5mg5mg£148.00
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TAR-T21331-1mL1 mL * 10 mM (in DMSO)£164.00
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TAR-T21331-10mg10mg£209.00
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TAR-T21331-25mg25mg£349.00
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TAR-T21331-50mg50mg£516.00
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TAR-T21331-100mg100mg£699.00
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Further Information

Bioactivity:
SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.
CAS:
1184843-57-9
Formula:
C19H19ClN6O
Molecular Weight:
382.85
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9778
SMILES:
C[C@H](CN(C)C)Oc1nc(Nc2cc3cccc(Cl)c3cn2)cnc1C#N
Target:
Chk

References

1. Walton M I , Eve P D , Hayes A , et al. The Preclinical Pharmacology and Therapeutic Activity of the Novel CHK1 Inhibitor SAR-020106[J]. Molecular Cancer Therapeutics, 2010, 9(1):89-100. 2. Klair S , Matthews T P , Cheung K M J , et al. Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing[J]. Journal of Medicinal Chemistry, 2011, 54(24):8328-42.