TargetMol

HATU

Product Code:
 
TAR-T21354
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21354-5mg5mg£111.00
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Quantity:
TAR-T21354-10mg10mg£127.00
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TAR-T21354-25mg25mg£162.00
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TAR-T21354-50mg50mg£205.00
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TAR-T21354-100mg100mg£270.00
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Quantity:
TAR-T21354-500mg500mg£500.00
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Further Information

Bioactivity:
HATU is a reagent used in peptide coupling chemistry to generate an active ester from a carboxylic acid. HATU is used along with H?nig's base (N,N-diisopropylethylamine, DIPEA) to form amide bonds.
CAS:
148893-10-1
Formula:
C10H15F6N6OP
Molecular Weight:
380.235
Purity:
0.98
SMILES:
F[P-](F)(F)(F)(F)F.CN(C)C(On1nnc2cccnc12)=[N+](C)C

References

1. Aaronson JG, Klein LJ, Momose AA, O'Brien AM, Shaw AW, Tucker TJ, Yuan Y, Tellers DM. Rapid HATU-mediated solution phase siRNA conjugation. Bioconjug Chem. 2011 Aug 17;22(8):1723-8. doi: 10.1021/bc2001227. Epub 2011 Jul 11. PubMed PMID: 21744777. 2. Ho?y?ska M, Kubiak M. Supramolecular motifs in the first structures of organic carboxylate salts of 1-(diaminomethylene)thiourea (HATU). Acta Crystallogr C. 2009 Aug;65(Pt 8):o410-3. doi: 10.1107/S0108270109026390. Epub 2009 Jul 15. PubMed PMID: 19652326. 3. Xiao Z, Yang MG, Li P, Carter PH. Synthesis of 3-substituted-4(3H)-quinazolinones via HATU-mediated coupling of 4-hydroxyquinazolines with amines. Org Lett. 2009 Mar 19;11(6):1421-4. doi: 10.1021/ol802946p. PubMed PMID: 19243133. 4. Yung A, Papworth-Smith J, Wilkinson SM. Occupational contact urticaria from the solid-phase peptide synthesis coupling agents HATU and HBTU. Contact Dermatitis. 2003 Aug;49(2):108-9. PubMed PMID: 14641366.