TargetMol

Emedastine Difumarate

Product Code:
 
TAR-T21388
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T21388-5mg5mg£850.00
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Further Information

Bioactivity:
Emedastine Difumarate is a selective histamine H1 receptor antagonist with anti-allergic activity, prescribed for allergic conjunctivitis. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva.
CAS:
87233-62-3
Formula:
C25H34N4O9
Molecular Weight:
534.566
Purity:
0.98
SMILES:
OC(=O)C=CC(O)=O.OC(=O)C=CC(O)=O.CCOCCn1c(nc2ccccc12)N1CCCN(C)CC1

References

1. Murota H, Katayama I. Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases. Expert Opin Pharmacother. 2009 Aug;10(11):1859-67. doi: 10.1517/14656560903078410. Review. PubMed PMID: 19558341. 2. Tian Y, Zhang Z, Liang J, Li W, Chen Y. High-performance liquid chromatography-electrospray ionization-mass spectrometric determination of emedastine difumarate in human plasma and its pharmacokinetics. J Chromatogr Sci. 2007 Mar;45(3):158-64. PubMed PMID: 17462131. 3. Pons-Guiraud A, Nekam K, Lahovsky J, Costa A, Piacentini A. Emedastine difumarate versus loratadine in chronic idiopathic urticaria: a randomized, double-blind, controlled European multicentre clinical trial. Eur J Dermatol. 2006 Nov-Dec;16(6):649-54. PubMed PMID: 17229605. 4. Corrado ME, Radicioni MM, Hartwig J, Assandri A, Oldeman HG, Mion A. Clinical study of the therapeutic efficacy and safety of emedastine difumarate versus terfenadine in the treatment of seasonal allergic rhinitis. Arzneimittelforschung. 2004;54(10):660-5. PubMed PMID: 15553105.