TargetMol

Chlorcyclizine HCl

Product Code:
 
TAR-T21396
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T21396-5mg5mg£850.00
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Further Information

Bioactivity:
Chlorcyclizine is used primarily to treat allergy symptoms such as rhinitis, pruritus, and urticaria, and may also be used as an antiemetic. In addition to its antihistamine effects, chlorcyclizine also has some antiserotonergic, anticholinergic, and local anesthetic properties.
CAS:
1620-21-9
Formula:
C18H22Cl2N2
Molecular Weight:
337.29
Purity:
0.98
SMILES:
CN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1.[H]Cl

References

1. He S, Xiao J, Dulcey AE, Lin B, Rolt A, Hu Z, Hu X, Wang AQ, Xu X, Southall N, Ferrer M, Zheng W, Liang TJ, Marugan JJ. Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection. J Med Chem. 2015 Nov 24. [Epub ahead of print] PubMed PMID: 26599718. 2. He S, Lin B, Chu V, Hu Z, Hu X, Xiao J, Wang AQ, Schweitzer CJ, Li Q, Imamura M, Hiraga N, Southall N, Ferrer M, Zheng W, Chayama K, Marugan JJ, Liang TJ. Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection. Sci Transl Med. 2015 Apr 8;7(282):282ra49. doi: 10.1126/scitranslmed.3010286. PubMed PMID: 25855495. 3. Enright BP, Gu YZ, Snyder RD, Dugyala RR, Obert LA, Treinen KA, McIntyre BS, Veneziale RW. Effects of the histamine H1 antagonist chlorcyclizine on rat fetal palate development. Birth Defects Res B Dev Reprod Toxicol. 2010 Dec;89(6):474-84. doi: 10.1002/bdrb.20261. PubMed PMID: 21058326. 4. Kvisselgaard N. Chlorpromazine and chlorcyclizine in the prevention of postoperative nausea and vomiting. Acta Anaesth. Scandinav. 1958, 2, 153-162. Acta Anaesthesiol Scand. 2007 Sep;51(8):979-88; discussion 989-90. PubMed PMID: 17697290.