TargetMol

SP-141

Product Code:
 
TAR-T21773
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21773-1mg1mg£101.00
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TAR-T21773-5mg5mg£139.00
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TAR-T21773-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T21773-10mg10mg£175.00
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TAR-T21773-25mg25mg£302.00
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TAR-T21773-50mg50mg£457.00
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TAR-T21773-100mg100mg£623.00
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This product comes from: United States.
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Further Information

Bioactivity:
SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.
CAS:
1253491-42-7
Formula:
C22H16N2O
Molecular Weight:
324.383
Pathway:
Apoptosis
Purity:
0.9921
SMILES:
COc1ccc2[nH]c3c(nccc3c2c1)-c1cccc2ccccc12
Target:
Mdm2

References

1. Wei Wang, et al. The Pyrido[b]indole MDM2 Inhibitor SP-141 Exerts Potent Therapeutic Effects in Breast Cancer Models. Nat Commun. 2014 Oct 1;5:5086. 2. Wei Wang , et al. Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice. Gastroenterology. 2014 Oct;147(4):893-902.e2.