TargetMol

Bis(maltolato)oxovanadium(IV)

Product Code:
 
TAR-T22276
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T22276-5mg5mg£102.00
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TAR-T22276-1mL1 mL * 10 mM (in DMSO)£105.00
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TAR-T22276-10mg10mg£118.00
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TAR-T22276-25mg25mg£168.00
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TAR-T22276-50mg50mg£229.00
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TAR-T22276-100mg100mg£322.00
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TAR-T22276-200mg200mg£446.00
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TAR-T22276-500mg500mg£675.00
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Further Information

Bioactivity:
BMOV is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases)inhibitor with insulin-mimicking effects and anti-diabetic properties. BMOV is a potent insulin sensitize. BMOV is shown to improve cardiac dysfunctions in diabetic models. BMOV inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectivelyr[1][2].
CAS:
38213-69-3
Formula:
C12H10O7V
Molecular Weight:
317.15
Pathway:
; Metabolism
Purity:
0.991
SMILES:
CC(OC=C1)=C([O-]2)C1=O[V+2]23(O=C4C=COC(C)=C4[O-]3)=O
Target:
Phosphatase;

References

1. Janine Kr?ger, et al. Inhibition of Src homology 2 domain-containing phosphatase 1 increases insulin sensitivity in high-fat diet-induced insulin-resistant mice. FEBS Open Bio. 2016 Jan 4;6(3):179-89. 2. Kevin G Peters, et al. Mechanism of insulin sensitization by BMOV (bis maltolato oxo vanadium); unliganded vanadium (VO4) as the active component. J Inorg Biochem. 2003 Aug 1;96(2-3):321-30. 3. Cong XQ, et al. Biol Trace Elem Res. 2016 Oct;173(2):390-8.