TargetMol

Motesanib

Product Code:
 
TAR-T2288
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2288-5mg5mg£100.00
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TAR-T2288-10mg10mg£114.00
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TAR-T2288-1mL1 mL * 10 mM (in DMSO)£117.00
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TAR-T2288-50mg50mg£210.00
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This product comes from: United States.
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Further Information

Bioactivity:
Motesanib is an orally bioavailable receptor tyrosine kinase inhibitor with potential antineoplastic activity. AMG 706 selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), Kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation.
CAS:
453562-69-1
Formula:
C22H23N5O
Molecular Weight:
373.46
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.9887
SMILES:
CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12
Target:
VEGFR; c-Kit

References

1. Polverino A, et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer R 2. Kruser TJ, et al. Augmentation of radiation response by motesanib, a multikinase inhibitor that targets vascular endothelial growth factor receptors. Clin Cancer Res, 2010, 16(14), 3639-3647. 3. Coxon A, et al. Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and Kit receptors. Clin Cancer Res, 2009, 15(1), 110-118.