TargetMol

PHA 543613

Product Code:
 
TAR-T23145
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23145-1mg1mg£107.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T23145-1mL1 mL * 10 mM (in DMSO)£156.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T23145-5mg5mg£158.00
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Quantity:
TAR-T23145-10mg10mg£213.00
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Quantity:
TAR-T23145-25mg25mg£389.00
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Quantity:
TAR-T23145-50mg50mg£615.00
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Quantity:
TAR-T23145-100mg100mg£870.00
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Quantity:
TAR-T23145-500mg500mg£1,805.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Potent α7 nAChR agonist
CAS:
478149-53-0
Formula:
C15H18ClN3O2
Molecular Weight:
307.78
Pathway:
Others|Neuroscience
Purity:
0.98
SMILES:
Cl.O=C(NC1CN2CCC1CC2)c1cc2ccoc2cn1
Target:
Others|AChR

References

N?ra Bruszt, et al. Potentiation of cognitive enhancer effects of Alzheimer's disease medication memantine by alpha7 nicotinic acetylcholine receptor agonist PHA-543613 in the Morris water maze task. Psychopharmacology (Berl). 2021 Nov;238(11):3273-3281. Donn G Wishka, et al. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship. J Med Chem. 2006 Jul 13;49(14):4425-36. [Content Brief] Krafft PR, et al. ?7 nicotinic acetylcholine receptor agonism confers neuroprotection through GSK-3? inhibition in a mouse model of intracerebral hemorrhage.