TargetMol

Sulindac sulfone

Product Code:
 
TAR-T23403
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23403-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T23403-5mg5mg£111.00
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TAR-T23403-10mg10mg£131.00
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TAR-T23403-25mg25mg£173.00
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TAR-T23403-50mg50mg£225.00
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TAR-T23403-100mg100mg£301.00
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TAR-T23403-200mg200mg£417.00
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This product comes from: United States.
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Further Information

Bioactivity:
Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug sulindac. Sulindac sulfone is an inhibitor of aldose reductase (IC50 =367 nM).
CAS:
59864-04-9
Formula:
C20H17FO4S
Molecular Weight:
372.41
Pathway:
Immunology/Inflammation; Metabolism; Neuroscience; Endocrinology/Hormones
Purity:
0.98
SMILES:
CC1=C(CC(O)=O)c2cc(F)ccc2C1=Cc1ccc(cc1)S(C)(=O)=O
Target:
Reductase; COX

References

1. Zheng X, et al. The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase. FEBS Lett. 2012 Jan 2;586(1):55-9. 2. Kitamura S, Tatsumi K. In vitro metabolism of sulindac and sulindac sulfide: enzymatic formation of sulfoxide and sulfone. Jpn J Pharmacol. 1982 Oct;32(5):833-8. 3. Piazza GA, et al. Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels. Cancer Res. 1997 Jul 15;57(14):2909-15. 4. Sauter A, et al. Sulindac sulfone induces a decrease of beta-catenin in HNSCC. Anticancer Res. 2010 Feb;30(2):339-43.