TargetMol

Afeletecan free base

Product Code:
 
TAR-T23654
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23654-5mg5mg£850.00
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Further Information

Bioactivity:
Afeletecan is a water-soluble camptothecin derivative. Afeletecan stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA replication, double-strand DNA breakage, and triggering of apoptosis.
CAS:
215604-75-4
Formula:
C45H49N7O11S
Molecular Weight:
895.99
Purity:
0.98
SMILES:
[H][C@@](Cc1c[nH]cn1)(NC(=S)Nc1ccc(O[C@H]2O[C@@H](C)[C@@H](O)[C@@H](OC)[C@@H]2O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)O[C@]1(CC)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O

References

1. Bay?s M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Jul-Aug;25(6):483-506. PubMed PMID: 12949633. 2. Bay?s M, Rabasseda X, Prous JR. Gateways to clinical trials. March 2003. Methods Find Exp Clin Pharmacol. 2003 Mar;25(2):145-68. PubMed PMID: 12731460.