TargetMol

AFP-07 free acid

Product Code:
 
TAR-T23657L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T23657L-5mg5mg£1,572.00
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Quantity:
TAR-T23657L-50mg50mg£3,107.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T23657L-100mg100mg£4,247.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
AFP 07 free acid is a 7,7-difluoroprostacyclin derivative. It also acts as a selective and highly potent agonist for the IP receptor.
CAS:
788799-13-3
Formula:
C22H30F2O5
Molecular Weight:
412.474
Purity:
0.98
SMILES:
[H][C@@]12C[C@@H](O)[C@H](C=C[C@@H](O)[C@@H](C)CC#CCC)[C@H]1C(F)(F)C(O2)=CCCCC(O)=O

References

1. McCormick C, Jones RL, Kennedy S, Wadsworth RM. Activation of prostanoid EP receptors by prostacyclin analogues in rabbit iliac artery: implications for anti-restenotic potential. Eur J Pharmacol. 2010 Sep 1;641(2-3):160-7. doi: 10.1016/j.ejphar.2010.04.035. Epub 2010 May 5. PubMed PMID: 20450909. 2. Jones RL, Chan KM. Investigation of the agonist activity of prostacyclin analogues on prostanoid EP4 receptors using GW 627368 and taprostene: evidence for species differences. Prostaglandins Leukot Essent Fatty Acids. 2005 Apr;72(4):289-99. PubMed PMID: 15763441. 3. Chan KM, Jones RL. Partial agonism of taprostene at prostanoid IP receptors in vascular preparations from guinea-pig, rat, and mouse. J Cardiovasc Pharmacol. 2004 Jun;43(6):795-807. PubMed PMID: 15167273. 4. Chow KB, Jones RL, Wise H. Agonists can discriminate between cloned human and mouse prostacyclin receptors. Prostaglandins Leukot Essent Fatty Acids. 2004 May;70(5):423-9. PubMed PMID: 15062844.