TargetMol

Tipiracil hydrochloride

Product Code:
 
TAR-T2366
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2366-5mg5mg£112.00
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TAR-T2366-10mg10mg£132.00
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TAR-T2366-25mg25mg£166.00
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TAR-T2366-50mg50mg£201.00
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TAR-T2366-100mg100mg£244.00
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TAR-T2366-200mg200mg£295.00
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Quantity:
TAR-T2366-500mg500mg£446.00
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This product comes from: United States.
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Further Information

Bioactivity:
Tipiralacil is a thymidine phosphorylase inhibitor (TPI). Tipiracil is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials.
CAS:
183204-72-0
Formula:
C9H12Cl2N4O2
Molecular Weight:
279.12
Pathway:
DNA Damage/DNA Repair; Cell Cycle/Checkpoint
Purity:
0.9945
SMILES:
Cl.Clc1c(CN2CCCC2=N)[nH]c(=O)[nH]c1=O
Target:
Nucleoside Antimetabolite/Analog

References

1. Peters GJ, et al. TAS-102: more than an antimetabolite. Lancet Oncol. 2012 Dec;13(12):e518-9. 2. Yoshino T, et al. TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol. 2012 Oct;13(10):1993-12001. 3. Belcher A, Zulfiker A H M, Li O Q, et al. Targeting Thymidine Phosphorylase With Tipiracil Hydrochloride Attenuates Thrombosis Without Increasing Risk of Bleeding in Mice[J]. Arteriosclerosis, Thrombosis, and Vascular Biology. 2020: ATVBAHA. 120.315109.