TargetMol

Aganodine

Product Code:
 
TAR-T23662
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23662-5mg5mg£930.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-T23662-50mg50mg£1,821.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T23662-100mg100mg£2,319.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
Aganodine is a guanidine that activates presynaptic imidazoline receptors. Aganodine inhibits the presynaptic release of norepinephrine through its agonism at imidazoline receptors.
CAS:
86696-87-9
Formula:
C9H10Cl2N4
Molecular Weight:
245.11
Purity:
0.98
SMILES:
NC(=N)NN1Cc2c(C1)c(Cl)ccc2Cl

References

1. Molderings GJ, B?nisch H, Hammermann R, G?thert M, Br?ss M. Noradrenaline release-inhibiting receptors on PC12 cells devoid of alpha(2(-)) and CB(1) receptors: similarities to presynaptic imidazoline and edg receptors. Neurochem Int. 2002 Feb;40(2):157-67. PubMed PMID: 11738482. 2. S?nchez-Bl?zquez P, Boronat MA, Olmos G, Garc?a-Sevilla JA, Garz?n J. Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol. 2000 May;130(1):146-52. PubMed PMID: 10781010; PubMed Central PMCID: PMC1572044. 3. Molderings GJ, Likungu J, G?thert M. Presynaptic cannabinoid and imidazoline receptors in the human heart and their potential relationship. Naunyn Schmiedebergs Arch Pharmacol. 1999 Aug;360(2):157-64. PubMed PMID: 10494885. 4. G?thert M, Br?ss M, B?nisch H, Molderings GJ. Presynaptic imidazoline receptors. New developments in characterization and classification. Ann N Y Acad Sci. 1999 Jun 21;881:171-84. Review. PubMed PMID: 10415912.