TargetMol

Amiclenomycin

Product Code:
 
TAR-T23724
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T23724-5mg5mg£850.00
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This product comes from: United States.
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Further Information

Bioactivity:
Amiclenomycin is an antibiotic. It has activity against mycobacterium.
CAS:
53696-70-1
Formula:
C10H16N2O2
Molecular Weight:
196.25
Purity:
0.98
SMILES:
NC(CCC1C=CC(N)C=C1)C(O)=O

References

1. Gehrke SS, Kumar G, Yokubynas NA, C?t? JP, Wang W, French S, MacNair CR, Wright GD, Brown ED. Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites. ACS Infect Dis. 2017 Dec 8;3(12):955-965. doi: 10.1021/acsinfecdis.7b00149. Epub 2017 Nov 7. PubMed PMID: 29069544. 2. Eiden CG, Aldrich CC. Synthesis of a 3-Amino-2,3-dihydropyrid-4-one and Related Heterocyclic Analogues as Mechanism-Based Inhibitors of BioA, a Pyridoxal Phosphate-Dependent Enzyme. J Org Chem. 2017 Aug 4;82(15):7806-7819. doi: 10.1021/acs.joc.7b00847. Epub 2017 Jul 26. PubMed PMID: 28682613; PubMed Central PMCID: PMC5590672. 3. Shi C, Aldrich CC. Design and synthesis of potential mechanism-based inhibitors of the aminotransferase BioA involved in biotin biosynthesis. J Org Chem. 2012 Jul 20;77(14):6051-8. doi: 10.1021/jo3008435. Epub 2012 Jul 3. PubMed PMID: 22724679; PubMed Central PMCID: PMC3448953. 4. Mann S, Ploux O. Pyridoxal-5'-phosphate-dependent enzymes involved in biotin biosynthesis: structure, reaction mechanism and inhibition. Biochim Biophys Acta. 2011 Nov;1814(11):1459-66. doi: 10.1016/j.bbapap.2010.12.004. Epub 2010 Dec 21. Review. PubMed PMID: 21182990.