TargetMol

BRP-7

Product Code:
 
TAR-T23824
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23824-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T23824-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T23824-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
BRP-7 is an inhibitor of 5-LO activating protein.
CAS:
612046-20-5
Formula:
C29H25ClN2O
Molecular Weight:
452.98
Purity:
0.98
SMILES:
CC(c1nc2ccccc2n1Cc1ccccc1Cl)c1ccc(OCc2ccccc2)cc1

References

1. Levent S, Gerstmeier J, Olga? A, Nikels F, Garscha U, Carotti A, Macchiarulo A, Werz O, Banoglu E, ?al??kan B. Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7. Eur J Med Chem. 2016 Oct 21;122:510-519. doi: 10.1016/j.ejmech.2016.07.004. Epub 2016 Jul 5. PubMed PMID: 27423639. 2. Pergola C, Gerstmeier J, M?nch B, ?al??kan B, Luderer S, Weinigel C, Barz D, Maczewsky J, Pace S, Rossi A, Sautebin L, Banoglu E, Werz O. The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP). Br J Pharmacol. 2014 Jun;171(12):3051-64. doi: 10.1111/bph.12625. PubMed PMID: 24641614; PubMed Central PMCID: PMC4055205.