TargetMol

CEP-2563

Product Code:
 
TAR-T23873
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23873-5mg5mg£2,135.00
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TAR-T23873-50mg50mg£4,231.00
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Quantity:
TAR-T23873-100mg100mg£5,934.00
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This product comes from: United States.
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Further Information

Bioactivity:
CEP-2563 is a prodrug of CEP-751. It also used as an antitumor agent, inhibiting protein kinases.
CAS:
183488-70-2
Formula:
C36H44Cl2N6O6
Molecular Weight:
727.68
Purity:
0.98
SMILES:
Cl.Cl.[H][C@@]12CC3=C(C=C1)c1c4C=NC=c4c4c5C(=O)CCC=c5n5CC=C/[C@](C)(O2)[N]3(COC(=O)CCNC(=O)[C@@H](N)CCCCN)(OC)c1c45

References

1. Undevia SD, Vogelzang NJ, Mauer AM, Janisch L, Mani S, Ratain MJ. Phase I clinical trial of CEP-2563 dihydrochloride, a receptor tyrosine kinase inhibitor, in patients with refractory solid tumors. Invest New Drugs. 2004 Nov;22(4):449-58. PubMed PMID: 15292715. 2. Strock CJ, Park JI, Rosen M, Dionne C, Ruggeri B, Jones-Bolin S, Denmeade SR, Ball DW, Nelkin BD. CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth. Cancer Res. 2003 Sep 1;63(17):5559-63. PubMed PMID: 14500395. 3. Ho R, Eggert A, Hishiki T, Minturn JE, Ikegaki N, Foster P, Camoratto AM, Evans AE, Brodeur GM. Resistance to chemotherapy mediated by TrkB in neuroblastomas. Cancer Res. 2002 Nov 15;62(22):6462-6. PubMed PMID: 12438236. 4. Ruggeri BA, Miknyoczki SJ, Singh J, Hudkins RL. Role of neurotrophin-trk interactions in oncology: the anti-tumor efficacy of potent and selective trk tyrosine kinase inhibitors in pre-clinical tumor models. Curr Med Chem. 1999 Sep;6(9):845-57. Review. PubMed PMID: 10495355.