TargetMol

DA-11004

Product Code:
 
TAR-T23945
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23945-5mg5mg£850.00
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Quantity:
TAR-T23945-50mg50mg£1,661.00
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Quantity:
TAR-T23945-100mg100mg£2,079.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
DA-11004 is a potent NADP-dependent isocitrate dehydrogenase inhibitor (IC50: 1.49 μM for IDPc). DA-11004 inhibited fatty acid synthesis in adipose tissues via IDPc inhibition. It also decreased the plasma glucose levels and FFA in HF diet-induced obesity of C57BL/6J mice.
CAS:
57404-51-0
Formula:
C11H9NO2
Molecular Weight:
187.198
Purity:
0.98
SMILES:
CNC1=CC(=O)C(=O)c2ccccc12

References

1. Shin CY, Jung MY, Lee IK, Son M, Kim DS, Lim JI, Kim SH, Yoo M, Huh TL, Sohn YT, Kim WB. Anti-diabetic effects of DA-11004, a synthetic IDPc inhibitor in high fat high sucrose diet-fed C57BL/6J mice. Arch Pharm Res. 2004 Jan;27(1):48-52. PubMed PMID: 14969338. 2. O'Dell LE, Parsons LH. Serotonin1B receptors in the ventral tegmental area modulate cocaine-induced increases in nucleus accumbens dopamine levels. J Pharmacol Exp Ther. 2004 Nov;311(2):711-9. Epub 2004 Jun 28. PubMed PMID: 15226384. 3. Lin D, Parsons LH. Anxiogenic-like effect of serotonin(1B) receptor stimulation in the rat elevated plus-maze. Pharmacol Biochem Behav. 2002 Apr;71(4):581-7. PubMed PMID: 11888549. 4. Parsons LH, Koob GF, Weiss F. RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine. Synapse. 1999 May;32(2):132-5. PubMed PMID: 10231132.