TargetMol

DI-404

Product Code:
 
TAR-T23989
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23989-5mg5mg£1,332.00
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Quantity:
TAR-T23989-50mg50mg£2,625.00
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Quantity:
TAR-T23989-100mg100mg£3,524.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
DI-404 is a high-Affinity Peptidomimetic the DCN1-UBC12 Protein-Protein Interaction inhibitor (Kd= 6.9 nM). DI-404 effectively and selectively inhibits the neddylation of cullin 3 over other cullin members.
CAS:
2187412-79-7
Formula:
C35H45ClN6O6S
Molecular Weight:
713.29
Purity:
0.98
SMILES:
CCC(=O)N[C@@H](Cc1nc2ccc(Cl)cc2s1)C(=O)N[C@@H](C1CCOCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]1CCOc2ccccc12

References

1. ZHou HB, Zhou W, Zhou B, Liu L, Chern TR, Chinnaswamy K, Lu J, Bernard D, Yang C, Li S, Wang M, Stuckey JA, Sun Y, Wang S. High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction. J Med Chem. 2018 Feb 13. doi: 10.1021/acs.jmedchem.7b01455. [Epub ahead of print] PubMed PMID: 29438612.