TargetMol

FFPM

Product Code:
 
TAR-T24061
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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This product comes from: United States.
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Further Information

Bioactivity:
FFPM is a novel PDE4 inhibitor (IC50: 6 nM) and good selectivity over other PDEs. The drug also penetrates the blood brain barrier well.
CAS:
1093412-18-0
Formula:
C16H20F2O4
Molecular Weight:
314.329
Purity:
0.98
SMILES:
CC(C)CC(=O)c1ccc(OC(F)F)c(OC2CCOC2)c1

References

1. Guo H, Cheng Y, Wang C, Wu J, Zou Z, Niu B, Yu H, Wang H, Xu J. FFPM, a PDE4 inhibitor, reverses learning and memory deficits in APP/PS1 transgenic mice via cAMP/PKA/CREB signaling and anti-inflammatory effects. Neuropharmacology. 2017 Apr;116:260-269. doi: 10.1016/j.neuropharm.2017.01.004. Epub 2017 Jan 6. PubMed PMID: 28065587. 2. Wu Y, Li Z, Huang YY, Wu D, Luo HB. Novel Phosphodiesterase Inhibitors for Cognitive Improvement in Alzheimer's Disease. J Med Chem. 2018 Feb 5. doi: 10.1021/acs.jmedchem.7b01370. [Epub ahead of print] PubMed PMID: 29363967.