TargetMol

Gastrazole free acid

Product Code:
 
TAR-T24085
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-T24085-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24085-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24085-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
Gastrazole is a CCK2 receptor antagonist potentially. It also used for the treatment of pancreatic cancer.
CAS:
174610-98-1
Formula:
C34H34FN5O7
Molecular Weight:
643.672
Purity:
0.98
SMILES:
OC(=O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3nc[nH]c3cc2C(=O)NCC2CCCCCC2)cc(c1)C(O)=O

References

1. Black JW. Reflections on some pilot trials of gastrin receptor blockade in pancreatic cancer. Eur J Cancer. 2009 Feb;45(3):360-4. doi: 10.1016/j.ejca.2008.11.026. Epub 2009 Jan 7. Review. PubMed PMID: 19131241. 2. Rudholm T, Wallin B, Theodorsson E, N?slund E, Hellstr?m PM. Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats. Regul Pept. 2009 Jan 8;152(1-3):8-12. doi: 10.1016/j.regpep.2008.10.002. Epub 2008 Oct 10. PubMed PMID: 18992283. 3. Chau I, Cunningham D, Russell C, Norman AR, Kurzawinski T, Harper P, Harrison P, Middleton G, Daniels F, Hickish T, Prendeville J, Ross PJ, Theis B, Hull R, Walker M, Shankley N, Kalindjian B, Murray G, Gillbanks A, Black J. Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials. Br J Cancer. 2006 Apr 24;94(8):1107-15. PubMed PMID: 16622436; PubMed Central PMCID: PMC2361246. 4. Freedman JM, Barrett TD, Shankley NP. A novel, quantitative bio-assay for cholecystokinin type-1 receptor activity in the anaesthetised rat. J Pharmacol Toxicol Methods. 2006 Jul-Aug;54(1):36-41. Epub 2005 Oct 24. PubMed PMID: 16246596.