TargetMol

GGTI-2133

Product Code:
 
TAR-T24088
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-T24088-1mg1mg£306.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24088-5mg5mg£650.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24088-10mg10mg£863.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24088-25mg25mg£1,267.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24088-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24088-100mg100mg£2,287.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
GGTI-2133 is a peptidomimetic geranylgeranyltransferase type I inhibitor (GGTase I; IC50: 38 nM). GGTI-2133 inhibits infiltration of inflammatory cells into airways in mouse experimental asthma.
CAS:
191102-79-1
Formula:
C27H28N4O3
Molecular Weight:
456.546
Pathway:
Metabolism
Purity:
0.98
SMILES:
CC(C)C[C@H](NC(=O)c1ccc(NCc2cnc[nH]2)cc1-c1cccc2ccccc12)C(O)=O
Target:
Transferase

References

1. Abdullah MI, Abed MN, Richardson A. Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells. Sci Rep. 2017 Aug 14;7(1):8090. doi: 10.1038/s41598-017-08649-9. PubMed PMID: 28808351; PubMed Central PMCID: PMC5556066. 2. Vilimanovich U, Bosnjak M, Bogdanovic A, Markovic I, Isakovic A, Kravic-Stevovic T, Mircic A, Trajkovic V, Bumbasirevic V. Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells. Eur J Pharmacol. 2015 Oct 15;765:415-28. doi: 10.1016/j.ejphar.2015.09.004. Epub 2015 Sep 8. PubMed PMID: 26358205. 3. Hui KP, Kuok DI, Kang SS, Li HS, Ng MM, Bui CH, Peiris JS, Chan RW, Chan MC. Modulation of sterol biosynthesis regulates viral replication and cytokine production in influenza A virus infected human alveolar epithelial cells. Antiviral Res. 2015 Jul;119:1-7. doi: 10.1016/j.antiviral.2015.04.005. Epub 2015 Apr 13. PubMed PMID: 25882623. 4. Ohsawa M, Mutoh J, Yamamoto S, Hisa H. Involvement of protein isoprenylation in neuropathic pain induced by sciatic nerve injury in mice. Neurosci Lett. 2014 Apr 3;564:27-31. doi: 10.1016/j.neulet.2014.01.039. Epub 2014 Jan 30. PubMed PMID: 24486886.