TargetMol

GR 122222X

Product Code:
 
TAR-T24100
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24100-5mg5mg£1,894.00
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TAR-T24100-50mg50mg£3,749.00
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Quantity:
TAR-T24100-100mg100mg£5,211.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
GR 122222X is an inhibitor of topoisomerase II.
CAS:
161161-54-2
Formula:
C26H35N5O11S2
Molecular Weight:
657.71
Purity:
0.98
SMILES:
C[C@H](N)C(=O)N([C@@H](C)C(=O)OC(=O)c1c(C)c(O)cc(O)c1CS)C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H]1NCC[C@H]1O)C=S

References

1. Sa?z-Urra L, Cabrera P?rez M?, Helguera AM, Froeyen M. Combining molecular docking and QSAR studies for modelling the antigyrase activity of cyclothialidine derivatives. Eur J Med Chem. 2011 Jul;46(7):2736-47. doi: 10.1016/j.ejmech.2011.03.061. Epub 2011 Apr 5. PubMed PMID: 21530019. 2. Gevi M, Domenici E. A scintillation proximity assay amenable for screening and characterization of DNA gyrase B subunit inhibitors. Anal Biochem. 2002 Jan 1;300(1):34-9. PubMed PMID: 11743689. 3. Lewis RJ, Singh OM, Smith CV, Skarzynski T, Maxwell A, Wonacott AJ, Wigley DB. The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography. EMBO J. 1996 Mar 15;15(6):1412-20. PubMed PMID: 8635474; PubMed Central PMCID: PMC450046. 4. Oram M, Dosanjh B, Gormley NA, Smith CV, Fisher LM, Maxwell A, Duncan K. Mode of action of GR122222X, a novel inhibitor of bacterial DNA gyrase. Antimicrob Agents Chemother. 1996 Feb;40(2):473-6. PubMed PMID: 8834902; PubMed Central PMCID: PMC163138.