TargetMol

ICL-SIRT078

Product Code:
 
TAR-T24158
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24158-5mg5mg£850.00
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TAR-T24158-50mg50mg£1,661.00
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Quantity:
TAR-T24158-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
ICL-SIRT078 is a highly selective inhibitor of substrate-competitive SIRT2 that acts by displaying a significant neuroprotective effect in a lactacystin-induced model of Parkinsonian neuronal cell death in the N27 cell line.
CAS:
1060430-64-9
Formula:
C28H26N4O2S
Molecular Weight:
482.6
Purity:
0.98
SMILES:
COc1ccc2ccccc2c1Cn1cnc2sc3CC(CCc3c2c1=O)NCc1cccnc1

References

1. Di Fruscia P, Zacharioudakis E, Liu C, Moniot S, Laohasinnarong S, Khongkow M, Harrison IF, Koltsida K, Reynolds CR, Schmidtkunz K, Jung M, Chapman KL, Steegborn C, Dexter DT, Sternberg MJ, Lam EW, Fuchter MJ. The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model. ChemMedChem. 2015 Jan;10(1):69-82. doi: 10.1002/cmdc.201402431. Epub 2014 Nov 13. PubMed PMID: 25395356.