TargetMol

L 645151

Product Code:
 
TAR-T24300
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24300-5mg5mg£850.00
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Quantity:
TAR-T24300-50mg50mg£1,661.00
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Quantity:
TAR-T24300-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
L 645151 is an inhibitor of lipophilic CA.
CAS:
86394-94-7
Formula:
C12H14N2O4S2
Molecular Weight:
314.37
Purity:
0.98
SMILES:
CC(C)(C)C(=O)Oc1ccc2nc(sc2c1)S(N)(=O)=O

References

1. Wetzel P, Kleinke T, Papadopoulos S, Gros G. Inhibition of muscle carbonic anhydrase slows the Ca(2+) transient in rat skeletal muscle fibers. Am J Physiol Cell Physiol. 2002 Oct;283(4):C1242-53. PubMed PMID: 12225987. 2. Wetzel P, Papadopoulos S, Gros G. Inhibition of muscle carbonic anhydrase increases rise and relaxation times of twitches in rat skeletal muscle fibres. Pflugers Arch. 2002 Mar;443(5-6):762-70. Epub 2002 Jan 22. PubMed PMID: 11889574. 3. Woltersdorf OW Jr, Schwam H, Bicking JB, Brown SL, deSolms SJ, Fishman DR, Graham SL, Gautheron PD, Hoffman JM, Larson RD, et al. Topically active carbonic anhydrase inhibitors. 1. O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide. J Med Chem. 1989 Nov;32(11):2486-92. PubMed PMID: 2810337. 4. Bar-Ilan A, Pessah NI, Maren TH. Ocular penetration and hypotensive activity of the topically applied carbonic anhydrase inhibitor L-645,151. J Ocul Pharmacol. 1986 Spring;2(2):109-20. PubMed PMID: 3503100.