TargetMol

L-771688 dihydrochloride

Product Code:
 
TAR-T24378
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24378-5mg5mg£930.00
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TAR-T24378-50mg50mg£1,821.00
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Quantity:
TAR-T24378-100mg100mg£2,319.00
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Further Information

Bioactivity:
L-771688 is an α1A-adrenoceptor antagonist potentially for the treatment of benign prostatic hyperplasia.
CAS:
200051-19-0
Formula:
C28H35Cl2F2N5O5
Molecular Weight:
630.51
Purity:
0.98
SMILES:
Cl.Cl.COCC1=C([C@@H](N(C(=O)NCCCN2CCC(CC2)c2ccccn2)C(=O)N1)c1ccc(F)c(F)c1)C(=O)OC

References

1. Xu F, Huang D, Lin X, Wang Y. Highly enantioselective Biginelli reaction catalyzed by SPINOL-phosphoric acids. Org Biomol Chem. 2012 Jun 14;10(22):4467-70. doi: 10.1039/c2ob25663k. Epub 2012 May 8. PubMed PMID: 22565820. 2. Li N, Chen XH, Song J, Luo SW, Fan W, Gong LZ. Highly enantioselective organocatalytic Biginelli and Biginelli-like condensations: reversal of the stereochemistry by tuning the 3,3'-disubstituents of phosphoric acids. J Am Chem Soc. 2009 Oct 28;131(42):15301-10. doi: 10.1021/ja905320q. Erratum in: J Am Chem Soc. 2010 Aug 11;132(31):10953. PubMed PMID: 19785440. 3. Winchell GA, Mistry GC, Kari PP, Marbury T, Miller JL, Simpson RC, Rodrigues AD, Gottesdiener KM, Wagner JA. The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist. J Clin Pharmacol. 2005 Jun;45(6):699-703. PubMed PMID: 15901753. 4. Chang RS, Chen TB, O'Malley SS, Pettibone DJ, DiSalvo J, Francis B, Bock MG, Freidinger R, Nagarathnam D, Miao SW, Shen Q, Lagu B, Murali Dhar TG, Tyagarajan S, Marzabadi MR, Wong WC, Gluchowski C, Forray C. In vitro studies on L-771,688 (SNAP 6383), a new potent and selective alpha1A-adrenoceptor antagonist. Eur J Pharmacol. 2000 Dec 15;409(3):301-12. PubMed PMID: 11108825.