TargetMol

MI-1481

Product Code:
 
TAR-T24463
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24463-5mg5mg£1,572.00
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TAR-T24463-50mg50mg£3,107.00
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Quantity:
TAR-T24463-100mg100mg£4,247.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
MI-1481 is an effective MML1 inhibitor (IC50: 3.6 nM). MI-1481 showed very potent inhibition of the menin-MLL1 interaction (IC50: 3.6 nM). MI-1481 also demonstrates pronounced activity in MLL leukemia cells and in vivo in MLL leukemia models.
CAS:
1887178-64-4
Formula:
C29H30F3N7O2S
Molecular Weight:
597.66
Purity:
0.98
SMILES:
Cc1c(CN2CCC(CC2)Nc2ncnc3sc(CC(F)(F)F)cc23)ccc2n(C[C@@H]3CNC(=O)CO3)c(cc12)C#N

References

1. Borkin D, Klossowski S, Pollock J, Miao H, Linhares B, Kempinska K, Jin Z, Purohit T, Wen B, He M, Sun D, Cierpicki T, Grembecka J. The complexity of blocking bivalent protein-protein interactions: development of a highly potent inhibitor of the menin-Mixed Lineage Leukemia (MLL) interaction. J Med Chem. 2018 May 8. doi: 10.1021/acs.jmedchem.8b00071. [Epub ahead of print] PubMed PMID: 29738674.