TargetMol

Mixanpril

Product Code:
 
TAR-T24473
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24473-5mg5mg£850.00
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TAR-T24473-50mg50mg£1,661.00
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Quantity:
TAR-T24473-100mg100mg£2,079.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
Mixanpril is an RB 105 lipophilic prodrug.
CAS:
156039-69-9
Formula:
C21H23NO4S
Molecular Weight:
385.48
Purity:
0.98
SMILES:
C[C@H](NC(=O)[C@@H](CSC(=O)c1ccccc1)[C@@H](C)c1ccccc1)C(O)=O

References

1. Lassila M, Davis BJ, Allen TJ, Burrell LM, Cooper ME, Cao Z. Cardiovascular hypertrophy in diabetic spontaneously hypertensive rats: optimizing blockade of the renin-angiotensin system. Clin Sci (Lond). 2003 Apr;104(4):341-7. PubMed PMID: 12653675. 2. Arbin V, Claperon N, Fourni?-Zaluski MC, Roques BP, Peyroux J. Effects of dual angiotensin-converting enzyme and neutral endopeptidase 24-11 chronic inhibition by mixanpril on insulin sensitivity in lean and obese Zucker rats. J Cardiovasc Pharmacol. 2003 Feb;41(2):254-64. PubMed PMID: 12548087. 3. Arbin V, Claperon N, Fourni?-Zaluski MC, Roques BP, Peyroux J. Acute effect of the dual angiotensin-converting enzyme and neutral endopeptidase 24-11 inhibitor mixanpril on insulin sensitivity in obese Zucker rat. Br J Pharmacol. 2001 Jun;133(4):495-502. PubMed PMID: 11399666; PubMed Central PMCID: PMC1572809. 4. Fourni?-Zaluski MC, Gonzalez W, Turcaud S, Pham I, Roques BP, Michel JB. Dual inhibition of angiotensin-converting enzyme and neutral endopeptidase by the orally active inhibitor mixanpril: a potential therapeutic approach in hypertension. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4072-6. PubMed PMID: 8171037; PubMed Central PMCID: PMC43725.