TargetMol

MK-8325

Product Code:
 
TAR-T24480
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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CodeSizePrice
TAR-T24480-1mg1mg£376.00
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TAR-T24480-5mg5mg£785.00
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TAR-T24480-10mg10mg£1,058.00
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TAR-T24480-1mL1 mL * 10 mM (in DMSO)£1,348.00
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TAR-T24480-25mg25mg£1,540.00
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TAR-T24480-50mg50mg£2,062.00
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Quantity:
TAR-T24480-100mg100mg£2,761.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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  • Further Information
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Further Information

Bioactivity:
MK-8325 is an effective HCV NS5A inhibitor. It also has excellent replicon activity across multiple genotypes. In vitro and in vivo assays showed MK-8325 to be orally bioavailable with pharmacokinetics suitable for once-daily dosing in patients and good overall ADME profiles.
CAS:
1334314-19-0
Formula:
C43H54Cl2F2N8O6Si
Molecular Weight:
915.94
Pathway:
Microbiology/Virology|Proteases/Proteasome
Purity:
0.98
SMILES:
Cl.Cl.COC(=O)N[C@@H](C(C)C)C(=O)N1CC(F)(F)C[C@H]1c1ncc([nH]1)-c1ccc(cc1)-c1ccc2c3[nH]c(nc3ccc2c1)[C@@H]1C[Si](C)(C)CN1C(=O)[C@@H](NC(=O)OC)C(C)C
Target:
HCV Protease

References

1. Yu W, Vibulbhan B, Rosenblum SB, Martin GS, Vellekoop AS, Holst CL, Coburn CA, Wong M, Selyutin O, Ji T, Zhong B, Hu B, Chen L, Dwyer MP, Jiang Y, Nair AG, Tong L, Zeng Q, Agrawal S, Carr D, Rokosz L, Liu R, Curry S, McMonagle P, Ingravallo P, Lahser F, Asante-Appiah E, Fells J, Kozlowski JA. Discovery of potent macrocyclic HCV NS5A inhibitors. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3793-9. doi: 10.1016/j.bmcl.2016.05.042. Epub 2016 May 17. PubMed PMID: 27282743.